A review of applications and scope of intrauterine proteolytic enzymes therapy for treatment of uterine infections in dairy animals

The target of one calf crop per year in dairy cattle and 13-14 months buffaloes could be achieved only when an animal normally calves, completes uterine involution timely with initiation post-partum ovarian activity. But, the postpartum infections pose a great hurdle achievement this due to economic losses owe cost treatment, disturbed calving conception period therefore prolonged inter-calving interval. Various types antimicrobials are used for treatment animals which results its withdrawal milk ultimately leading arising antimicrobial resistance as well human beings ultimate consumers products. Therefore, research is on-going throughout world have alternative therapies aim reduce veterinarian resistance. Many like immune-modulators, metritis vaccines, bacteriophage therapy, ozone interleukins etc. been tried variable success world. Intrauterine proteolytic enzymes therapy that our lab mainly focussing prevention therapeutics various grades infections. This review shall focus on mechanism action enzymes, their efficacy different future perspectives related therapy.